Electron Transport Complex IV

A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.

Also Known As:

Cytochrome c Oxidase; Oxidase, Cytochrome; Cytochrome-c Oxidase (Complex IV); Cytochrome Oxidase; Cytochrome Oxidase Subunit III; Cytochrome a,a3; Cytochrome c Oxidase Subunit VIa; Cytochrome-c Oxidase Subunit III; Cytochrome-c Oxidase Subunit IV; Ferrocytochrome c Oxygen Oxidoreductase; Heme aa3 Cytochrome Oxidase; Pre-CTOX p25; Signal Peptide p25-Subunit IV Cytochrome Oxidase; Subunit III, Cytochrome Oxidase; p25 Presequence Peptide-Cytochrome Oxidase; Cytochrome c Oxidase Subunit III; Cytochrome c Oxidase Subunit IV; Oxidase, Cytochrome-c; Signal Peptide p25 Subunit IV Cytochrome Oxidase; p25 Presequence Peptide Cytochrome Oxidase; Cytochrome aa3; Cytochrome-c Oxidase; Ferricytochrome-c:oxygen oxidoreductase

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Multienzyme Complexes: 8
    - Electron Transport Complex IV: 2202
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Electron Transport Complex IV: 2202
  - Multienzyme Complexes: 8
    - Electron Transport Chain Complex Proteins
      - Electron Transport Complex IV: 2202
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Cation Transport Proteins: 22
        Proton Pumps: 415
        Electron Transport Complex IV: 2202
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Cation Transport Proteins: 22
        Proton Pumps: 415
        Electron Transport Complex IV: 2202
    - Electron Transport Chain Complex Proteins
      - Electron Transport Complex IV: 2202

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Disease

Drug/Important Bio-Agent (IBA)